Sr. Scientist-High Throughput Receptor Pharmacology (Bristol Myers Squibb)

Job Description

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.  Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. 

Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro.   LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency.  Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology.  The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate.  Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

The Lead Discovery & Optimization Group leverages technology, innovation, and broad scientific knowledge to deliver comprehensive in vitro data packages to support all phases of early drug discovery at BMS. We are seeking a highly motivated and innovative scientist to drive the development and implementation of cell-based assays supporting multiple therapeutic areas. This candidate will be expected to have a breadth of cell-based assay and in vitro pharmacology expertise to support drug discovery projects from hit identification through lead optimization. Applicants should have a deep scientific and technical understanding of high-throughput screening techniques to develop complex cell-based, automated screening assays for application across drug discovery programs. The candidate should possess strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders. He/she should demonstrate personal leadership within the group, scientific leadership both at the bench and at data analysis and be adept at multi-tasking. This position is a bench scientist role and will spend the majority of time in the lab for assay design and screening.

Responsibilities:

• Collaborate closely with therapeutic area scientists to devise optimal strategies for the execution of cell-based drug discovery support within LDO.
• Ability to manage multiple projects simultaneously.
• Identify, evaluate, and implement new technologies and methods to improve upon the quality and efficiency of high-throughput receptor in vitro pharmacology HTS campaigns and SAR profiling
• Review relevant literature and leverage knowledge to solve problems in a timely fashion.
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• Identify new cell technologies and reduce them to routine practice
• Analyze, interpret, and effectively present data at team meetings.

Basic Qualifications:

Bachelor’s Degree 7+ years of academic/industry experience

or

Master’s Degree 5+ years of academic/industry experience

or

PhD with 2+ years of academic / industry experience

Preferred Qualifications:

• Ph.D. in pharmacology, cell biology, or related field with in-depth experience in cell-based assay design and 2+ years of experience .
• Expertise and extensive knowledge of complex cell surface receptor pharmacology including GPCR, ion channels and transporters is required.
• Extensive experience in assay design in recombinant, primary and iPSC cellular environments for hit identification, hit assessment, lead optimization and mechanism of action studies.
• Experience with immune or neuro signaling pathways a plus
• Ability to apply new technology advances and scientific knowledge in the high-throughput screening field for drug discovery program support is required.
  • Establish and validate novel/standard assays in-house and ensure reliability and reproducibility of screening results and methods
  • Provide in-depth knowledge and scientific leadership for cell-based assays
  • Expertise in the application of GPCR, ion channel, and transporter technologies and methodologies and ability to scale assays for high-throughput screening for a range of drug modalities
• Knowledge of ion flux technologies such as FLIPR and/or FDSS and high-throughput electrophysiology technologies and associated data analysis is absolutely required.
• Experience in assay miniaturization to 1536-well formats and/or acoustic liquid handlers would be seen as an advantage.
• Skilled use of IT platforms for data handling, data reduction and data reporting would be a significant plus.Ability to create and maintain an effective scientific network through teamwork, excellent problem-solving skills and open collaborative style are of critical importance to the success of this role.
• High attention to detail, strong written and verbal communication skills, project management skills and ability to communicate scientific methods and results clearly. Candidate will be responsible for scientific presentations and reports for internal review meetings and scientific journals.
• An independent, flexible and high-energy scientist

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. 

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.